Gabriel Yulaw (Jet Li), once an officer of the "Multiverse Authority" (MVA) that polices interdimensional travel (via detecting wormholes), seeks to hunt down all variations of himself in alternate universes. By killing all 124 of his other selves (becoming the last version) and absorbing their life energies, he believes he will become an immortal godlike being called "The One". Yulaw is briefly captured by MVA agents Rodecker (Delroy Lindo) and Funsch (Jason Statham), only to escape from captivity during the trial sentencing him to life in the Stygian penal colony in the Hades universe.

The last known alternate, Gabriel (Gabe) Law, works in the Los Angeles County Sheriff's Department. For two years he has been experiencing increases in strength, speed and mental ability, but neither he nor his wife, T.K. Law (Carla Gugino), can understand why. While transporting a prisoner for the Sheriff's Department, Gabe "feels" Yulaw's presence just before he attempts to kill Gabe. Yulaw escapes, but is followed by Gabe, who inhumanly leaps a very high wall. Landing on the other side, Gabe is shot and wounded by Yulaw. As Yulaw approaches Gabe to finish him off, they are interrupted by Rodecker and Funsch.

Gabe realizes Yulaw is identical to him in every way. Not knowing about interdimensional travel, Yulaw's appearance is shocking. After checking into the hospital, Gabe feels Yulaw's presence again. There is another fight, which Rodecker and Funsch again foil. Yulaw deters them from shooting him because if he is killed, then Gabe would then be left as the only "One". Dressed alike and identical in every way, Gabe and Yulaw's battle confuses Gabe's police colleagues. Both Gabe and Yulaw manage to escape the hospital.

Rodecker is faced with a dilemma: they have to capture Yulaw, but they cannot kill him or allow Gabe to be killed because the other one will become "The One". Funsch insists that Yulaw, as the instigator, must be dealt with in a more aggressive manner. Rodecker makes a fateful decision to "go way off procedure" and split the team. Rodecker pursues and fights Yulaw and is killed when Yulaw breaks his neck. Funsch catches up with Gabe and tells him about the multiverse and why he has become stronger. Yulaw finds Gabe's residence where TK, believing it is Gabe, attempts to protect him, but she senses he is not her husband. Gabe arrives, only to have Yulaw force him to watch while he kills her. Funsch finds Gabe and they team up to find Yulaw at the next wormhole.

Yulaw, Gabe and Funsch arrive at the industrial plant, where the final battle between Gabe and Yulaw takes place. When Gabe eventually wins, all three are caught in a wormhole and taken back to the MVA headquarters in the Alpha Universe. Yulaw is transported immediately to the prison colony universe after a last attempt to switch places with Gabe. The MVA then prepares to send Gabe back to his own universe where he will be arrested and put in prison for the murders Yulaw committed, but Agent Funsch instead sends him to a universe similar to Gabe's past via another wormhole, after recalling an earlier conversation Gabe told him about the events which led up to him meeting his wife.

Meanwhile, Yulaw, now in the Stygian penal colony, declares he will still become the One; standing at the top of a Ziggurat in the Hades universe, Yulaw battles hundreds of fighters as the credits roll.

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