The story is set in between the events of Resident Evil 6 and Resident Evil 7: Biohazard. BSAA agent Chris Redfield is tracking Glenn Arias, a Brazilian-American death merchant and a former CIA operative who is wanted by both the Interpol and FBI. Arias is on a mission of vengeance against the U.S. government for killing his family, friends, and wife in a drone strike at their wedding. Chris and his fellow agents infiltrate a mansion in Mexico, after Cathy White, their undercover source who followed Arias's organization vanished along with her son, Zack. Inside the mansion, Chris's fellow agents are ambushed by aggressive zombies (Zack included) and death traps, with Chris being the sole survivor and barely making it out alive. Chris then comes face-to-face with Arias outside the mansion and engages him in close quarters combat only to be swiftly defeated. He then finds out that Cathy has become a zombie, who now obeys Arias. As Arias leaves with his associates, Maria and Diego Gomez, the BSAA arrives just in time to rescue Chris by slaughtering Cathy and the remaining zombie horde with Chris vowing revenge on Arias. Meanwhile, Professor Rebecca Chambers, former S.T.A.R.S. unit member and survivor of the Mansion incident, studies a new virus coined the "Animality Virus"

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